Project information
Cellular and extracellular environment for the axon regenaration following injury of the spinal roots and peripheral nerves
- Project Identification
- GA309/00/0407
- Project Period
- 1/2000 - 1/2002
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
In contrast to the CNS environment, the peripheral nerves of mammals provide cellular and extracellular conditions supporting the regeneration of axons. The supporting conditions originate distal to the point of injury during Wallerian degeneration that results in formation of immature Schwann cells. The cells restore the production of molecules which promote axonal regrowth. The synthesis of axon-promoting molecules by Schwann cells and suitable content of their extracellular matrix are important extri nsic factors influencing the axon regeneration in the peripheral nervous systém. Some recent reports suggest that the cellular and extracellular environment is probably not the same for regeneration of motor and somatosensory axons in the peripheral ner ves. In addition, formation of different extrinsic cues supporting the axonal regeneration of the motor and somatosensory axons in the damaged peripheral nerves as well as the ventral and dorsal spinal roots of the rats. The spatial-temporal changes of t
Publications
Total number of publications: 26
2006
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Immunohistochemical labelling of components of the endoneurial extracellular matrix of intact and rhizotomized dorsal and ventral spinal roots of the rat - a quantitative evaluation using image analysis
Acta histochemica, year: 2006, volume: 107, edition: 6
2005
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Extrinsic endoneurial cues for sorting of regenerated sensory and motor axons in the peripheral nervous system
Progress in Basic, Applied and Diagnostic Histochemistry, year: 2005
2004
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Schwann cells and endoneurial extracellular matrix molecules as potential cues for sorting of regenerated axons: A review
Anatomical Science International, year: 2004, volume: 79, edition: 2
2003
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Changes of immunofluorescence staining for ECM molecules in the satellite cells of rat dorsal root ganglia following a chronic constriction injury of the peripheral nerve
Glia Suppl, year: 2003, volume: 2, edition: 1
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Quantitative immunofluorescence for BDNF, NGF and NT-3 in Schwann cells of the spinal roots and peripheral nerve.
The Histochemical Journal, year: 2003, volume: 34, edition: 1
2002
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A QUANTITATIVE IMMUNOFLUORESCENCE ANALYSIS OF SOME ECM MOLECULES AND NEUROTROPHINS ALONGSIDE AFFERENT AND MOTOR AXONS IN THE DORSAL AND VENTRAL SPINAL ROOTS
Glia, year: 2002, volume: Suppl. 1, edition: 1
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A quantitative immunohistochemical study of the endoneurium in the rat dorsal and ventral spinal roots
Histochemistry and Cell Biology, year: 2002, volume: 117, edition: 6
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Computer-assisted quantitative immunohistochemistry of the extracellular matrix in the dorsal and ventral spinal roots with the use of a Lucia software
Acta histochemica, year: 2002, volume: 104, edition: 4
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Immunofluorescence staining of the insulin-like growth factor-I in the ventral and dorsal spinal roots
Scripta medica, year: 2002, volume: 2002, edition: 75
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Quantitative immunofluorescence for BDNF, NGF, and NT-3 in Schwann cells of the spinal roots and peripheral nerve
Progress in Basic, Applied, and Diagnostic Histochemistry, year: 2002