Project information
The use interphase FISH for the determination of individuals with elevated risk of the induction of hemoblastoses
- Project Identification
- NM15
- Project Period
- 1/1998 - 1/2000
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- Molecular Biology Methods Implementation in Diagnosis and Cure
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
Analysingthe chromatin structure of interphase cell nuclei the patients with elevated risk of cancer induction will be determined.FISH technique,fluorescence and confocal microscopy will be used.
Publications
Total number of publications: 10
2001
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Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays
International Journal of Radiation Biology, year: 2001, volume: 77, edition: 4
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Spatial distribution of selected genetic loci in nuclei of human leukemia cells after irradiation
Radiation Research, year: 2001, volume: 155, edition: 2
2000
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Influence of cell fixation on chromatin topography
Analytical Biochemistry, year: 2000, volume: 282, edition: 1
-
Nuclear topography of the c-myc gene in human leukemic cells
Gene, year: 2000, volume: 244, edition: 1
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Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation
Chromosome Research, year: 2000, volume: 8, edition: 6
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The influence of the cell cycle, differentiation and irradiation on the nuclear location of the ABL, BCR and C-MYC genes in human leukemic cells
Leukemia Research, year: 2000, volume: 24, edition: 3
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Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high-resolution image analysis techniques
Analytical Cellular Pathology, year: 2000, volume: 20, edition: 4
1999
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Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH
Fundamentals for the assesment of risks from environmental radiation, year: 1999
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Chromosomes participating in translocations typical of malignant hemoblastoses are also involved in exchange aberrations induced by fast neutrons
Radiation Research, year: 1999, volume: 151, edition: 4
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The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias
Chromosoma, year: 1999, volume: 108, edition: 7