Project information
Elucidating the role and molecular mechanism of Neuratin (NNAT) in neural induction
(NEURALDEVESTEM)
- Project Identification
- 2SGA2878
- Project Period
- 4/2011 - 3/2013
- Investor / Pogramme / Project type
-
South-Moravian Region
- SoMoPro
- Incoming grants
- MU Faculty or unit
- Faculty of Medicine
Our novel findings show Nnat initiates neural induction in mouse ES cells through
increasing intracellular Ca2+ ([Ca2+]i) by antagonising Ca2+ -ATPase (Sarco/ Endoplasmic
Reticulum Ca2+-ATPase, SERCA isoform 2, SERCA2) in the endoplasmic reticulum, which in turn
increases the phosphorylation of Erk1/2 and inhibits the BMP4 pathway, leading to neural induction
in conjunction with FGF/Erk pathway (Fig. 1) (2) (for more details, please see section 3.2). Based
on this we propose that NNAT plays a similar role in hES cells.
Publications
Total number of publications: 1
2013
-
PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells
Cell stem cell, year: 2013, volume: 13, edition: 6, DOI