Project information
Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
(INCHEMBIOL)
- Project Identification
- MSM0021622412
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Science
- Keywords
- -
Basic objective of the research plan is complex approach to study of interactions among chemical compounds present in environmental compartments and their biological effects, study of the fate of mainly persistent chemical compounds in the environment, their effects on the environment and living organisms including human.
Fate in this concept consists of a summary of transport (from their input in the environment, transport within the environmental compartment, where they are discharged, transport among compartments and long-range transport in the environment) and transformation processes (abiotic and biotic transformations). It also includes study of distribution equilibriums, properties conditioning their environmental behaviour, study of the transformation processes and their products.
This complex approach is a part of long-term research activities of the centre RECETOX. It is based on exploration of the causality among chemical (presence of chemical compounds in the environment) and biological (mechanisms of effects on the living organisms) part of the problem of chemical contamination of the environment.
This complex approach requires interdisciplinary, team collaboration of specialists from number of natural sciences and is very demanding on equipment and financial sources.
The submitted research plan concentrates on acquirement of new scientific information and experimental data concerned with problem of chemical contamination of the environment with persistent, toxic compounds (persistent, organic pollutants, heavy metals, organometallic compounds). It is necessary to distinguish this contamination from natural migration of the compounds in atmosphere, biosphere and geosphere, and also study its interactions within these environmental spheres.
The basic objective of the research plan is characterization of fate and negative effects of chemical compounds in real ecosystems by interconnection of a few scientific disciplines studying:
chemical compounds in the environment - fate - transport and transformation, distribution in and among compartments; their determination in different abiotic and biotic environmental components,
abiotic processes in the environment - differentiation and migration of the compounds in the atmosphere and geosphere - geology, geochemistry, paleontology and climatology
effects of chemical compounds on living organisms – biochemical toxicology, genotoxicology, ecotoxicology, ecological epidemiology;
ecologic and human risks combining knowledge of more disciplines for quantification of existing risks
Results
Publications
Total number of publications: 1716
2011
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CAVER 3.0: A Tool For Efficient Analysis Of Tunnels In Dynamic Protein Structures
Year: 2011, type: Appeared in Conference without Proceedings
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Centrum pro tezke kovy a metalomicky vyzkum: NanoBioMetalomika
V. Letni elektrochemicka skola, year: 2011
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CETOCOEN project: From the Laboratory to the Field and Beyond
9th IFIP WG 5.11 International Symposium on Environmental Software Systems: Frameworks of eEnvironment, ISESS 2011, year: 2011
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Combined dendro-documentary evidence of Central European hydroclimatic springtime extremes over the last millennium
Quaternary Science Reviews, year: 2011, volume: Vol. 30, edition: Iss. 27-28, DOI
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Combined exposure of Japanese quails to cyanotoxins, Newcastle virus and lead: Oxidative stress responses
Ecotoxicology and Environmental Safety, year: 2011, volume: 74, edition: 7, DOI
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Complex evaluation of ecotoxicity and genotoxicity of antimicrobials oxytetracycline and flumequine used in aquaculture.
Environmental Toxicology and Chemistry, year: 2011, volume: 30, edition: 5, DOI
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Construction of pollutant-degrading bacteria by protein and metabolic engineering
Year: 2011, type:
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Crystallization and Crystallographic Analysis of the Rhodococcus rhodochrous NCIMB 13064 DhaA Mutant DhaA31 and its Complex with 1,2,3-Trichloropropane
Acta Crystallographica F, year: 2011, volume: 67, edition: 67, DOI
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Crystallization and Preliminary Crystallographic Analysis of Rhodococcus rhodochrous Wild-type DhAa Protein and its Variant DhaA13 Complexed with Different Ligands
Year: 2011, type: Appeared in Conference without Proceedings
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Crystallization and Preliminary X-ray Diffraction Analysis of the Wild-Type Haloalkane Dehalogenase DhaA and its Variant DhaA13 Complexed with Different Ligands
Acta Crystallographica F, year: 2011, volume: 67, edition: 67, DOI