Project information
Application of computer image analysis in optical microscopy
- Project Identification
- MSM 143300002
- Project Period
- 1/1999 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Informatics
- Keywords
- image analysis; image processing; segmentation; preprocessing; deconvolution; 3D analysis; 3D reconstruction; mathematical morphology; parallel computing; parallel algorithms; optical microscopy; confocal microscopy; automation; automated microscopy
Aim: The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis. The proposal assumes both continuation of running research of cell nucleus structure with clinical applications in diagnostics and prevention of leukemias and other cancer diseases as well as extension of the research into other application areas of computer analysis of microscopic images, biomedical as well as industrial. Content: Especially the algorithms of image preprocessing and segmentation will be studied with emphasis on deconvolution of 3D images, mathematical morphology operations and 3D image reconstruction from a series of 2D image slices. An intensive research will be led also in the area of parallel image analysis algorithms and parallelization of selected algorithms on multi-processor workstations using the equipment of Supercomputing centre MU.
Results
The aim of the project is the research in the field of computer analysis of microscopic images, in the field of automation of the acquisition process and on-line image analysis and application of gained knowledge in praxis.
Publications
Total number of publications: 88
2003
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Nuclear and territorial topography of chromosome telomeres in human lymphocytes
Experimental Cell Research, year: 2003, volume: 289, edition: 1
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Počítačové zpracování 2D a 3D obrazů buněk, buněčných jader, chromosomů a genů pomocí automatizované optické mikroskopie
Year: 2003, type:
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Precise 3D image alignment in micro-axial tomography
Journal of Microscopy, year: 2003, volume: 209, edition: 2
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Spherical Object Reconstruction Using Simplex Meshes from Sparse Data
Discrete Geometry for Computer Imagery, year: 2003
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Structural and functional characterization of uncoupling proteins: Alkylsulfonates as probes of UCP transport mechanism
Biophysics of the Genome, year: 2003
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Study of the gene expression in malignant diseases by cDNA microarray technology
Biophysics of the Genome, year: 2003
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Tissue image reconstruction: Localization of nuclei markers and segmentation based on deformable models
Biophysics of the Genome, year: 2003
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Tissue Reconstruction Based on Deformation of Dual Simplex Meshes
Discrete Geometry for Computer Imagery, year: 2003
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Topography of telomeres and structure of chromosome territories in human lymphocytes
Biophysics of the Genome, year: 2003
2002
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3D Structure of the human genome: Order in randomness
Chromosoma, year: 2002, volume: 111, edition: 5