Project information
CZ-OPENSCREEN: National Infrastructure for Chemical Biology
(CZ-OPENSCREEN)
- Project Identification
- LM2015063
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
-
Institute of Molecular Genetics of the ASCR, v. v. i.
- Responsible person RNDr. Petr Bartůněk, CSc.
Prague Institute of Chemical Technology
The aim of the project „CZ-‐OPENSCREEN: National infrastructure for chemical
biology” is to operate the state-‐of-‐the-‐art infrastructure for basic and applied
research in the fields of chemical biology and genetics and provide Open Access to users. It will serve as the National node of the pan-European ESFRI infrastructure EU-‐OPENSCREEN, providing trans-‐national access to the
Screening platform and to the European Chemical Biology Library. The mission
of CZ-‐OPENSREEN is to identify new molecular probes/tools for research and
new potential therapeutics.
Publications
Total number of publications: 31
2019
-
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
EMBO reports, year: 2019, volume: 20, edition: 9, DOI
-
Cílená inhibice kasein kinázy 1 v léčbě chronické lymfoidní leukémie.
Year: 2019, type: Conference abstract
-
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS DISCOVERY, year: 2019, volume: 24, edition: 3, DOI
-
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Angewandte Chemie International Edition, year: 2019, volume: 58, edition: 4, DOI
-
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells
Haematologica, year: 2019, volume: 104, edition: 12, DOI
2018
-
Enantioselective Conjugate Additions of 2-Alkoxycarbonyl-3(2H)-furanones
Organic Letters, year: 2018, volume: 20, edition: 22, DOI
-
Furopyridines as inhibitors of protein kinases
Publisher: , state: United States of America, patent's number: US 9902733 B2, year: 2018
-
Furopyridines as inhibitors of protein kinases
Publisher: Japonský patentový úřad (JPO), state: Japan, patent's number: JP 6386585, year: 2018
-
Gram-scale Production of Recombinant Microbial Enzymes in Shake Flasks
FEMS Microbiology Letters, year: 2018, volume: 365, edition: 2, DOI
-
Impact of the access tunnel engineering on catalysis is strictly ligand-specific
the FEBS Journal, year: 2018, volume: 285/2018, edition: 8, DOI