Project information
Molecular organization of the zygotic spindle apparatus in non-rodent embryos

Information

This project doesn't include Institute of Computer Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification

MUNI/IGA/1127/2021

Project Period

1/2022 - 12/2022

Investor / Pogramme / Project type

Masaryk University

Internal grant agency MU

MU Faculty or unit

Faculty of Medicine

MUDr. Volodymyr Porokh

Despite scientific advances in reproductive medicine, embryo development still holds a myriad of secrets. The reset of the cell cycle machinery driving the unification and segregation of two parental genomes in the fertilized egg is fundamental to all mammals. The proposed work will shed new light on basic cell cycle mechanisms underlying the transition from acentrosomal female meiosis to the first mitotic division in which sperm centrioles assume control of microtubule organization.

Publications

Total number of publications: 3

2024

Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos

POROKH Volodymyr KYJOVSKA Drahomira MARTONOVA Martina KLENKOVA Tereza OTEVREL Pavel KLOUDOVÁ Soňa HOLUBCOVÁ Zuzana

Article in Periodical

Nature Communications, year: 2024, volume: 15, edition: 1, DOI

2022

ONE STEP CHEMICAL DERIVATIZATION OF SECRETED CELL METABOLITES FOR SENSITIVE MASS SPECTROMETRY DETECTION

PEČINKA Lukáš MORÁŇ Lukáš POROKH Volodymyr MARCHETTI-DESCHMANN Martina HAVEL Josef HAMPL Aleš VAŇHARA Petr

Conference abstract

Year: 2022, type: Conference abstract
The first cleavage plane in human embryos is dictated by the topology of pronuclei, not by the polar body position

POROKH Volodymyr KYJOVSKÁ Drahomíra MARTONOVÁ Martina KLENKOVÁ Tereza OTEVŘEL Pavel KLOUDOVÁ Soňa HOLUBCOVÁ Zuzana

Conference abstract

Year: 2022, type: Conference abstract