Project information
Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií
- Project Identification
- GAP304/10/1395
- Project Period
- 1/2010 - 12/2014
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- Monoclonal gammopathies; plasma cells; progenitors; phenotype; flow cytometry
Detailed study of heterogeneous subpopulations of myeloma cells and their precursors/progenitors in monoclonal gammopathy patients can lead to identification and characterisation of myeloma stem cells. Using polychromatic flow cytometry with sorting of cells, phenotype of myeloma stem cells can be detected and different subpopulation can be selected for clonality assessment. In vitro culturing then can prove self renewal capacity of these myeloma stem cells and their multidrug resistance as well. We suppose that using these approaches we are able to obtain new information in area of pathophysiology of myeloma cells and their behaviour, which can be potentially used for determination of predictive factors applicable in progression of monoclonal gammopaty of undetermined significance to multiple myeloma.
Publications
Total number of publications: 108
2010
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5th Myeloma workshop: Flow cytometry and cytogenetics: Application of flow cytometry and cytogenetics approach in monoclonal gammopathies and multiple myeloma
Year: 2010, type: Workshop
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A preliminary study report of T regulatory cells in pre and post treated myeloma patients
Year: 2010, type: Conference abstract
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An interim study report of CD44 standard molecule and its variant isoform expression in MGUS and MM
Year: 2010, type: Conference abstract
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Analýza subpopulací B lymfocytů v periferní krvi zdravých osob
Year: 2010, type: Conference abstract
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Assessment of Immune Regulatory and Suppressor Cells in Monoclonal Gammopathies
Year: 2010, type: Conference abstract
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Association of CD44s and their isoforms with prognostic features of multiple myeloma
Year: 2010, type: Conference abstract
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Association of plasma cell phenotype with cytogenetic findings in multiple myeloma
Year: 2010, type: Conference abstract
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FACS metóda - doležitý krok k úspěšnému molekulárne-cytogenetickému vyšetreniu u pacientov s monoklonálnou gamapatiou nejasného významu
Year: 2010, type: Conference abstract
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Flow Cytometric Phenotyping and Analysis of CD8 Regulatory and Suppressor Cells In Multiple Myeloma
Year: 2010, type: Conference abstract
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Heterogenní exprese markeru neuronálních kmenových buněk nestinu u pacientů s monoklonální gamapatií
Year: 2010, type: Conference abstract