New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Bioorganic & Medicinal Chemistry |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science/article/pii/S096808961300031X |
| Doi | http://dx.doi.org/10.1016/j.bmc.2013.01.004 |
| Field | Organic chemistry |
| Keywords | Polycyclic aromatic hydrocarbon (PAH);Nitrones;DNA;Intercalation;Docking |
| Attached files | |
| Description | Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure. |
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