The power is in detail - Structural analysis of an Aleuria aurantia lectin mutant

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Authors	HOUSER Josef MATUŠKA Radek KOZMON Stanislav ROMANO Patric KOČA Jaroslav WIMMEROVÁ Michaela
Year of publication	2013
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	We have crystallized one AAL mutant that has been proved to have stronger affinity towards a1-6 bound fucose. We were able to collect several datasets of high quality with resolution up to 1.09A. The detailed insight into the structure revealed the principal of the affinity change, shading the light upon variability of AAL’s binding sites differences. Furthermore, we utilized in silico approach to describe the contribution of particular amino acids in each of five AAL's binding sites.
Related projects:	CEITEC - Central European Institute of Technology SYLICA - Synergies of Life and Material Sciences to Create a New Future