Expression of FGF19 in Human Embryonic Stem Cells

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Authors	KREJČÍ Pavel KUNOVÁ Michaela KUBÍKOVÁ Iva TRANTÍREK Lukáš KOZUBÍK Alois DVOŘÁK Petr
Year of publication	2013
Type	Article in Periodical
Magazine / Source	STEM CELLS
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1002/stem.1493
Field	Genetics and molecular biology
Keywords	Cell signaling; Embryonic stem cells; FGF19; Fibroblast growth factor; Expression
Description	In human embryonic stem cells, continuous stimulation with fibroplast growthfactor 2 is required for self-renewal. inhibition of FGF2 signaling results in rapid differentiation, further underscoring the importance of FGF system in maintenance of hESC undifferentiated state. In addition to FGF2, human FGF family contains 17 members which presence in hESC remains unclear, with exception of FGF4.
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