CD36- and GPR120-mediated Ca2+ Signaling in Human Taste Bud Cells Mediates Differential Responses to Fatty Acids and is Altered in Obese Mice

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Authors	OZDENER Mehmet Hakan SUBRAMANIAM Selvakumar SUNDARESAN Sinju ŠERÝ Omar HASHIMOTO Toshihiro ASAKAWA Yoshinori BESNARD Philippe ABUMRAD Nada A. KHAN Naim Akhtar
Year of publication	2014
Type	Article in Periodical
Magazine / Source	Gastroenterology
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1053/j.gastro.2014.01.006
Field	Physiology
Keywords	Taste; human; Serotonin; Linoleic acid; GLP-1; Lipids
Description	It is important to increase our understanding of gustatory detection of dietary fat and its contribution to fat preference. We studied the roles of the fat taste receptors CD36 and GPR120 and their interactions via Ca2+ signaling in fungiform taste bud cells (TBC). CD36 and GPR120 have non-overlapping roles in TBC signaling during oro-gustatory perception of dietary lipids; these are differentially regulated by obesity.
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