A Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity

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Authors	HOUSER Josef KOMÁREK Jan KOSTLÁNOVÁ Nikola CIOCI Gianluca VARROT Annabelle KERR Sheena LAHMANN Martina BALLOY Viviane FAHY John CHIGNARD Michel IMBERTY Anne WIMMEROVÁ Michaela
Year of publication	2013
Type	Article in Periodical
Magazine / Source	PLOS ONE
MU Faculty or unit	Central European Institute of Technology
Citation
Web	Original article web page - full text free.
Doi	http://dx.doi.org/10.1371/journal.pone.0083077
Field	Biochemistry
Keywords	lectin; Aspergillus fumigatus; protein structure
Description	We focused on the lectin AFL, which was prepared in recombinant form and characterized. Its binding properties were studied using hemagglutination and glycan array analysis. We determined the specificity of the lectin towards L-fucose and fucosylated oligosaccharides. AFL was crystallized and its structure was solved. The combination of affinity to human epithelial epitopes, production by conidia and pro-inflammatory activity shows that AFL might be an important virulence factor
Related projects:	CEITEC - Central European Institute of Technology SYLICA - Synergies of Life and Material Sciences to Create a New Future Multidisciplinární přístup k návrhu léčiv - Inhibice proteinů s návazností na sacharidy Studium proteinu z patogenu zapojených do rozpoznávání hostitelského organismu