Spoločné neurobiologické mechanizmy depresie a metamfetamínovej závislosti

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Title in English	Common neurobiological mechanisms of depression and methamphetamine addiction
Authors	BABINSKÁ Zuzana KUČEROVÁ Jana
Year of publication	2014
Type	Article in Periodical
Magazine / Source	Alkoholizmus a drogové závislosti
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	addiction; depression; psychostimulants; metamphetamine
Description	Drug addiction and depression is the most common comorbidity, especially in case of secondary drug addiction of patients with depression. High comorbidity in population (30-50 %) may reflect shared neurobiogical abnormalities, aberrant neuroadaptation to acute drug effect leading to neurochemical changes, which have common elements with abnormalities connected to depression. Article presents review of neurobiological background of drug addiction and depression focused on amfetamine-like psychostimulants.
Related projects:	CEITEC - Central European Institute of Technology Vliv farmakologického ovlivnění serotonergního systému na metamfetaminovou závislost v animálním modelu komorbidity deprese a závislosti Farmakodynamické, farmakokinetické a farmakogenetické přístupy v preklinické fázi výzkumu a vývoje léčiv