Differences among binding sites of AAL family lectins - High affinity vs. high specificity of sugar binding

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Authors	HOUSER Josef KOMÁREK Jan CIOCI Gianluca IMBERTY Anne WIMMEROVÁ Michaela
Year of publication	2014
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	There are several lectins from opportunistic pathogens in the AAL lectin family. They share the same fold, however they differ in binding site organization and specificity. We combine the functional studies with X-ray crystallography in order to understand the properties of whole lectins as well as their individual binding sites.
Related projects:	CEITEC - Central European Institute of Technology SYLICA - Synergies of Life and Material Sciences to Create a New Future Multidisciplinární přístup k návrhu léčiv - Inhibice proteinů s návazností na sacharidy Studium proteinu z patogenu zapojených do rozpoznávání hostitelského organismu