Comparison of capillary electrophoresis and isothermal titration calorimetry for determination of the binding constant
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| Year of publication | 2015 |
| Type | Conference abstract |
| MU Faculty or unit | |
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| Description | The binding constant is commonly used to describe the strength of binding between ligands (drugs) and protein. The strength of the interaction has a significant effect on the biological activity of the drug, and knowledge of the nature and extent of drug-protein binding can help us to understand the pharmacokinetics and pharmacodynamics of a drug. The binding constant may be determined by various methods. The main objective of the study was to compare the results of capillary electrophoresis and isotermal titration calorimetry. |
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