Sequencing analysis of  PAX9  and  MSX1  genes  in the Czech population

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Authors	BONCZEK Ondřej ŠERÝ Omar HLOUŠKOVÁ Alena LOCHMAN Jan IZAKOVIČOVÁ HOLLÁ Lydie ŠOUKALOVÁ Jana ŠTEMBÍREK Jan MÍŠEK Ivan ČERNOCHOVÁ Pavlína KREJČÍ Přemysl VANĚK Jiří
Year of publication	2015
Type	Article in Proceedings
Conference	Morphology 2015
MU Faculty or unit	Faculty of Science
Citation
Web	Biomedical Papers, volume 159, Supplement 1
Doi	http://dx.doi.org/10.5507/bp.2015.042
Field	ORL, ophthalmology, stomatology
Keywords	PAX9; MSX1; tooth agenesis; oligodontia; mutation screening
Description	Tooth agenesis is one of the most common de- velopmental anomalies in humans. Tooth development (odontogenesis) is a very complicated and complex pro- cess that involves interplay between oral ectoderm and mesenchyme. These interactions are mediated by more than 350 signaling proteins. Synergistic and antagonistic interactions between these proteins may lead to local ac- tivation or inhibition of the expression. The aim of our study was to investigate the relationship between PAX9 and MSX1 genes variants and tooth agenesis in the Czech population.
Related projects:	Molekulární diagnostika hypodoncie a možnosti zubních autotransplantací