SERUM CARBOXYMETHYL-LYSINE, A DOMINANT ADVANCED GLYCATION END PRODUCT, IS INCREASED IN WOMEN WITH GESTATIONAL DIABETES MELLITUS
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| Year of publication | 2015 |
| Type | Conference abstract |
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| Description | Main Objectives: Gestational diabetes mellitus (GDM) is a common complication of pregnancy whose incidence is rising worldwide. Advanced Glycation End products (AGEs), are traditionally considered as a result of long-term dysregulation of glucose homeostasis, however detailed kinetic studies indicate a prompt reflexion of glucose metabolism. From this point of view - GDM represents a highly relevant phenotype to study acute changes of AGEs dynamics and its relationship to glucose metabolism. The objective of the study was to measure circulating AGEs - namely N?-(carboxymethyl)lysine (CML) - in case-control study (n=307) of pregnant women with GDM and physiological pregnancies and to ascertain the factors contributing to CML levels and the potential relevance of CML for selected perinatal and postpartum outcomes. Strategy and Methods: All subjects were Caucasians, Czech nationality. GDM screening was carried out using oral glucose tolerance test (oGTT) with 75g of glucose performed between 24th and 30th week of gestation and GDM was diagnosed according to WHO criteria. 222 women had GDM and 85 had physiologic pregnancy. CML was determined by ELISA using commercial kit. Main Results: Unadjusted and plasma protein adjusted CML levels were significantly higher in women with GDM compared to healthy controls (P= 0.00043 and P=1x10-5, respectively, Mann-Whitney). CML was significantly inversely correlated with both pre- and mid-gestational BMI, however, differences between GDM and control group remained significant even after adjustment for BMI. CML levels correlated with 1-hr and 2-r post-load glycaemia during oGTT. Plasma CML or plasma protein adjusted CML levels did not significantly correlated with offspring birth weight or pregnancy weight gain (P=NS, Spearman). Conclusions: In conclusion, we found statistically significantly higher protein- and BMI normalised CML levels measured during 24-30th week of gestation in women with GDM compared to healthy pregnant women. Further studies are warranted to more comprehensively asses the spectrum of AGEs in GDM and their relevance to future metabolic health of mother and baby. |
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