CD36 and GPR120 differently mediate Ca2+ signaling in human taste bud cells
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Proceedings |
| Conference | FUNDAMENTAL & CLINICAL PHARMACOLOGY |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1111/fcp.12064 |
| Field | Physiology |
| Keywords | oral; fat; lipid; taste; bud |
| Description | High concentrations of linoleic acid induced Ca(2+) signaling via CD36 and GPR120 in human and mice TBC, as well as in STC-1 cells, and low concentrations induced Ca(2+) signaling via only CD36. Incubation of human and mice fungiform TBC with lineoleic acid down-regulated CD36 and up-regulated GPR120 in membrane lipid rafts. Obese mice had decreased spontaneous preference for fat. Fungiform TBC from obese mice had reduced Ca(2+) and serotonin responses, but increased release of glucagon-like peptide-1, along with reduced levels of CD36 and increased levels of GPR120 in lipid rafts. CONCLUSIONS: CD36 and GPR120 have nonoverlapping roles in TBC signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity. |
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