(SALD) ICP-MS to examine the effect of copper on wedelolactone cytotoxicity towards breast cancer cells
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | CECE 2016 International Interdisciplinary Meeting on Bioanalysis |
| MU Faculty or unit | |
| Citation | |
| Field | Analytic chemistry |
| Keywords | SALD-ICP-MS-wedelolactone-cancer-cell |
| Description | In this study, the effect of copper on wedelolactone cytotoxicity towards breast cancer cells was examined. To monitor copper loading of cells, SALD ICP-MS (substrate assisted laser desorption inductively coupled plasma mass spectrometry) and conventional nebulizing ICP-MS analysis were used. The SALD technique provided direct and fast analysis of liquid samples in the form of dried droplets with minimal sample preparation and sub-microliter sample volume requirement. Furthermore, the SALD allowed direct analysis of samples in organic solvents, which could not be directly nebulised to ICP-MS. The experiments showed that copper chelation can drastically reduce wedelolactone cytotoxicity. |
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