DESORPTION/IONIZATION MASS SPECTROMETRY WITH SILVER NANOPARTICLES IN LIPID ANALYSIS
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | 13th International Interdisciplinary Meeting on Bioanalysis, CECE 2016 |
| MU Faculty or unit | |
| Citation | |
| Field | Analytic chemistry |
| Keywords | RP-LC MS; SALDI; silver nanoparticles; lipids; plasma |
| Description | This work aims at system optimization combining reversed phase liquid chromatography with on-line and off-line mass spectrometry detection. On-line detection was facilitated by APCI MS and off-line detection by SALDI MS using suspension of silver nanoparticles as matrix. Exploiting two different ionization mechanisms allowed obtaining complementary information from mass spectra of lipids. The application of the both techniques with high sensitivity and with low detection limits represents an alternative to GC-MS for analysis of nonpolar compounds. |
| Related projects: |