Analysis of Hemodynamic Related Changes in High Frequency Content of QRS Complex in Working Isolated Rabbit Heart
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Proceedings |
| Conference | 2017 COMPUTING IN CARDIOLOGY (CINC) |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.22489/CinC.2017.293-442 |
| Keywords | High Frequency Content of QRS Complex |
| Description | Aim: High frequency content of QRS complex (HF-QRS) is thought to be related to local conduction velocity (CV). There also exists the evidence suggesting the coupling between CV and mechanical stretch via so-called mechano-electric feedback. The aim of this study was to investigate possible relationship between left ventricular (LV) load and the most common HF-QRS parameters. Methods: Six isolated rabbit hearts in working mode underwent an experimental protocol consisting of upward and downward steps in preload (8-11 cmH(2)O). Eight unipolar pseudo-ECGs, left atrial pressure, and flow rate were recorded at f(s)=10 kHz and 16-bit resolution. QRS complexes from hemodynamically stable experiment phase were clustered, aligned, and decomposed into 3 HF-QRS bands followed by the assessment of power envelope RMS, the tallest peak value and its position. Results: No statistically significant changes associated with LV load alteration were observed in HF-QRS parameter. Conclusion: No evidence of load dependent changes in conduction velocity was found in the study. However, HF signal may represent a complex spatial depolarization behavior. Low sensitivity of used metrics should also be taken into consideration. |
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