Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting

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Authors	ŠTACKO Peter MUCHOVA Lucie VITEK Libor KLÁN Petr
Year of publication	2018
Type	Article in Periodical
Magazine / Source	Organic Letters
MU Faculty or unit	Faculty of Science
Citation
Web	https://pubs.acs.org/doi/10.1021/acs.orglett.8b02043
Doi	http://dx.doi.org/10.1021/acs.orglett.8b02043
Keywords	PHOTOREMOVABLE PROTECTING GROUPS; GASEOUS SIGNALING MOLECULE; PHOTODYNAMIC THERAPY; FLUORESCENT-PROBES; METHYLENE-BLUE; BODIPY DYES; GREEN-LIGHT; RELEASE; H2S; DERIVATIVES
Description	The synthesis and photochemical properties of H2S-releasing BODIPY thiocarbamate photocage scaffolds activatable by visible-to-NIR (up to 700 nm) light to release carbonyl sulfide (COS), which is transformed to H2S using either isolated or natural carbonic anhydrase, is reported. The excellent uncaging cross section and high H2S release yields in in vitro experiments, including live-cell imaging, suggest that these photocages can serve as a platform for the bio-orthogonal phototriggered release within the tissue-transparent window.
Related projects:	Výzkumná infrastruktura RECETOX Visible light-activated photocaged molecules for biological applications RECETOX RI - OP VVV Fotoaktivace CO a H2S jako plynných signálních molekul pro biologické a medicinální aplikace