Deficiency of Sprouty Proteins in Mice Resemble Ciliopathic Phenotype
| Authors | |
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| Year of publication | 2019 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The Sprouty family of proteins is a highly conserved group of intracellular modulators of receptor tyrosine kinase signaling, including the fibroblast growth factor receptor (FGFR) pathway. There are four orthologs (Sprouty1-4) in mammals. During embryonic development and postnatal bone remodeling, tight regulation of FGFR signaling is essential in endochondral ossification and in bone and mineral homeostasis. |
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