Dysregulated expression of lncRNAs in glioblastoma multiforme and their association with overall survival

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This publication doesn't include Institute of Computer Science. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	VEČEŘA Marek OPPELT Jan RADOVÁ Lenka LIPINA Radim REGULI S. SMRČKA Martin JANCALEK R. FILIP M. HERMANOVA M. KREN L. ŠÁNA Jiří KOPKOVÁ Alena BOHOŠOVÁ Júlia SLABÝ Ondřej
Year of publication	2019
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Glioblastoma multiforme (GBM) is the most frequent primary brain malignancy of astrocytic origin. The prognosis remains very poor with the median overall survival (OS) being between 12 and 16 months from diagnosis despite early use of conventional medical therapy. Identifying new therapeutic targets, as well as prognostic and predictive biomarkers for accurate stratification of patients is therefore of utmost importance. Long non-coding RNAs (lncRNAs) are regulators of gene expression having critical impact on both physiological processes and the molecular pathology of GBM, indicating their potential as biomarkers and therapeutic targets.
Related projects:	CEITEC 2020 Identifikace nových prognostických markerů a terapeutických cílových molekul u sarkomu měkkých tkání Extension of established prognostic scores in brain metastases by microRNA profiling to tailor the post-operative personalized care