NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats

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Authors	RUDÁ Jana AMCHOVÁ Petra ŠIŠKA Filip TIZABI Yousef
Year of publication	2021
Type	Article in Periodical
Magazine / Source	The World Journal of Biological Psychiatry
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.tandfonline.com/doi/full/10.1080/15622975.2021.1907714
Doi	http://dx.doi.org/10.1080/15622975.2021.1907714
Keywords	AMPA/kainate receptor; Nicotine; Methamphetamine; Self-administration; Relapse
Description	Pharmacological manipulations of glutamatergic ionotropic receptors have been suggested as a promising target for addiction treatment. Antagonists of AMPA/kainate receptors were shown to reduce alcohol intake or alcohol-seeking in various animal models. In this study, we evaluated the effect of NBQX, an AMPA/kainate receptor antagonist, on methamphetamine (METH) and nicotine self-administration in rats.
Related projects:	Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii