Pathogenesis of Retraction Pocket of the Tympanic Membrane - A Narrative Review

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Authors	URÍK Milan TEDLA Miroslav HURNÍK Pavel
Year of publication	2021
Type	Article in Periodical
Magazine / Source	Medicina
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.mdpi.com/1648-9144/57/5/425/htm
Doi	http://dx.doi.org/10.3390/medicina57050425
Keywords	retraction pocket; tympanic membrane; pathogenesis; pathology; chronic otitis media; cholesteatoma
Description	Several theories describe the development of the retraction pocket of the tympanic membrane (RP). Many authors suggest that the negative middle ear pressure is the main reason responsible for developing this condition. A narrative review has been undertaken, and conclusions are drawn reflecting a current knowledge with our new observations in the histological and immunohistochemical study. Recent studies show the important role of inflammation in the development and progression of RP. A review of the available literature shows that the inflammation plays a key role in pathogenesis of the RP and its progression to the cholesteatoma. We support this statement with our new results from histological and immunohistochemical analysis of the RPs.
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