Thermostable FGF2 Polypeptide, Use Thereof

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	DVOŘÁK Petr KREJČÍ Pavel BÁLEK Lukáš EISELLEOVÁ Lívia KONEČNÁ Žaneta DVOŘÁK Pavel BEDNÁŘ David BREZOVSKÝ Jan ŠEBESTOVÁ Eva CHALOUPKOVÁ Radka ŠTĚPÁNKOVÁ Veronika VAŇÁČEK Pavel PROKOP Zbyněk DAMBORSKÝ Jiří BOSÁKOVÁ Michaela
Year of publication	2021
Type	Patent
MU Faculty or unit	Faculty of Science
Publisher	Intellectual Property Office of Singapore (IPOS)
State	Singapore
Patent's number	SG11201804402W
Web	https://ip2sg.ipos.gov.sg/RPS/WP/CM/IPDetailsPTP.aspx?AppNbr=CcxXbwRr2MxjDY%2fjMWYMXDp%2bmch23TSPlTg6Y%2bD%2bf9SlLC%2bPBJrAxdk2B92KNfmZA8MZExJ62KPKn1EjUS2xVprvblh2lT%2bp4LNArEn%2be%2b%2fHT2wwS2dEIhhN0kg1L1M13bYOHCzsIULGQqWSpuAwuILRNRyq7M9mVQLq0Ph46%2fKEq
Attached files	40469SG2-CERT.PDF
Description	The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
Related projects:	Centrum pro výzkum toxických látek v prostředí Centrum pro výzkum toxických látek v prostředí