Mass Spectrometry Imaging Techniques Enabling Visualization of Lipid Isomers in Biological Tissues

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Authors	BEDNAŘÍK Antonín PRYSIAZHNYI Vadym BEZDEKOVÁ Dominika SOLTWISCH Jens DREISEWERD Klaus PREISLER Jan
Year of publication	2022
Type	Article in Periodical
Magazine / Source	Analytical Chemistry
MU Faculty or unit	Faculty of Science
Citation
Web	https://pubs.acs.org/doi/10.1021/acs.analchem.1c05108
Doi	http://dx.doi.org/10.1021/acs.analchem.1c05108
Keywords	mass spectrometry imaging; lipid isomers; double bond position; sn-position; chemical derivatization; biological tissues
Description	The feature article focuses on a review of recent developments in mass spectrometry imaging (MSI) of lipid isomers in biological tissues. The tandem MS techniques utilizing on-line and off-line chemical derivatization procedures, ion activation techniques such as ozone-induced dissociation (OzID), ultraviolet photodissociation (UVPD), or electron-induced dissociation (EID), and other techniques such as coupling of ion mobility with MSI are discussed. The importance of resolving lipid isomers in diseases is highlighted.
Related projects:	MALDI MS zobrazování izomerů lipidů lišících se pozicí dvojné vazby uhlík-uhlík