Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient

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Authors	ARPÁŠ Tomáš JELÍNKOVÁ Hana HRABOVSKÝ Štěpán ORŠULOVÁ Martina VRZALOVÁ Zuzana NAVRKALOVÁ Veronika BRHELOVÁ Eva BRYJOVÁ Lenka BULIKOVÁ Alena ONDROUŠKOVÁ Eva ŠEJNOHOVÁ Markéta FOLBER František ŠEDOVÁ Petra MAYER Jiří POSPÍŠILOVÁ Šárka JAROŠOVÁ Marie DOUBEK Michael
Year of publication	2022
Type	Article in Periodical
Magazine / Source	CLINICAL CASE REPORTS
MU Faculty or unit	Faculty of Medicine
Citation
web	https://onlinelibrary.wiley.com/doi/10.1002/ccr3.5545
Doi	http://dx.doi.org/10.1002/ccr3.5545
Keywords	acute lymphoblastic leukemia; blinatumomab; CAR-T therapy; inotuzumab ozogamicin; near-haploid
Description	Near-haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR-T therapy.
Related projects:	Personalized Medicine – Diagnostics and Therapy Analysis of Czech Genomes for Theranostics Involvement of Czech Translational Medicine Infrastructure to the European Advanced Translational Research Infrastructure in Medicine Searching and functional testing of gene variants predisposing to familial haematopoietic disorders Zavedení technologie CRISPR/Cas9 pro funkční studie u familiárních hematopoetických onemocnění Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit VIII