The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats
| Authors | |
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| Year of publication | 2022 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Harman is a heterocyclic aromatic amine discovered in coffee, cigarette smoke, roasted meat, or fish. However, carcinogenic properties of harmane were proved - partly explained by its interaction via the AhR receptor and induction of CYP1A1. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of 75 % of drugs used in clinical practice. Our study aimed to determine the effects of harman on the most important CYP variants in a preclinical experiment. |
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