Laser ablation imaging in bioapplications

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Authors	KUCHYNKA Michaela SCHEER Peter HLOŽKOVÁ Jana OPATŘILOVÁ Radka PADRTOVÁ Tereza KANICKÝ Viktor VLČNOVSKÁ Marcela VACULOVIČ Tomáš
Year of publication	2022
MU Faculty or unit	Faculty of Science
Citation
Description	In the last decades, increased interest in imaging of elements/metals/proteins distribution, mainly in pharmaceutical, biomedicine research, or life science with application to specific problems/diseases. The main emphasis of this paper is to demonstrate LA-ICP-MS as a unique method that opens new opportunities to achieve simultaneous determination of elements and proteins. These proteins are imaged by utilizing antibody labelling by nanoparticles. Therefore, it can be obtained comprehensive metalloproteomics information about diseases, in this case, cancer or brain stroke.
Related projects:	Analysis of tissue response to metal nanoparticles inhalation and mechanisms of their clearance Study the effectiveness of anticancer drugs