MAIA; Fc receptor-like 3; supersedes JUNO as IZUMO1 receptor during human fertilization
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | Science advances |
| MU Faculty or unit | |
| Citation | |
| web | https://www.science.org/doi/10.1126/sciadv.abn0047 |
| Doi | http://dx.doi.org/10.1126/sciadv.abn0047 |
| Keywords | human fertilization; MAIA; Fc receptor-like 3; supersedes JUNO; IZUMO1 |
| Description | Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes. |
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