Common xanthene fluorescent dyes are visible-light activatable CO-releasing molecules
| Authors | |
|---|---|
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | Organic and Biomolecular Chemistry |
| MU Faculty or unit | |
| Citation | |
| web | https://pubs.rsc.org/en/content/articlelanding/2023/OB/D2OB01823C |
| Doi | http://dx.doi.org/10.1039/d2ob01823c |
| Keywords | CARBON-MONOXIDE; QUANTUM YIELD; EOSIN-Y; PHOTOCHEMISTRY; OXYGEN; PHOTODEGRADATION; ANGIOGRAPHY; MECHANISM |
| Description | Fluorescein, eosin Y, and rose bengal are dyes used in clinical medicine and considered (photo-)chemically stable. Upon extensive irradiation with visible light in aqueous solutions, we found that these compounds release carbon monoxide (CO) - a bioactive gasotransmitter - in 40-100% yields along with the production of low-mass secondary photoproducts, such as phthalic and formic acids, in a multistep degradation process. Such photochemistry should be considered in applications of these dyes, and they could also be utilized as visible-light activatable CO-releasing molecules (photoCORMs) with biological implications. |
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