Phenotype Control of Partially Specified Boolean Networks

Beneš,  Nikola; Brim,  Luboš; Pastva,  Samuel; Šafránek,  David; Šmijáková,  Eva

Phenotype Control of Partially Specified Boolean Networks

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Authors	BENEŠ Nikola BRIM Luboš PASTVA Samuel ŠAFRÁNEK David ŠMIJÁKOVÁ Eva
Year of publication	2023
Type	Article in Proceedings
Conference	Computational Methods in Systems Biology
MU Faculty or unit	Faculty of Informatics
Citation
Web	https://link.springer.com/chapter/10.1007/978-3-031-42697-1_2
Doi	http://dx.doi.org/10.1007/978-3-031-42697-1_2
Keywords	Boolean networks;Partial specification;Permanent control;Phenotype;Perturbation;Symbolic algorithm
Description	Partially specified Boolean networks (PSBNs) represent a promising framework for the qualitative modelling of biological systems in which the logic of interactions is not completely known. Phenotype control aims to stabilise the network in states exhibiting specific traits. In this paper, we define the phenotype control problem in the context of asynchronous PSBNs and propose a novel semi-symbolic algorithm for solving this problem with permanent variable perturbations.
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