Nanodiamonds as artificial proteins for regulation of a cell signalling system

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Authors	CÍGLER Petr BÁLEK Lukáš HAVLÍK Jan KREJČÍ Pavel TRANTÍREK Lukáš TRANTÍRKOVÁ Silvie
Year of publication	2023
Type	Patent
MU Faculty or unit	Central European Institute of Technology
Publisher	United States Patent and Trademark Office
State	United States of America
Patent's number	US11744855B2
web	Link na PDF dokument na stránkách Google Patents
Description	Here, we show that nanosized diamond crystals (nanodiamonds, NDs) without any synthetically installed (bio)organic interface enable the specific and efficient targeting of the family of extracellular signalling molecules known as fibroblast growth factors (FGFs). We found that at certain conditions the ND strongly associate with multiple FGF ligands present at sub-nanomolar concentrations and effectively neutralize the effects of FGF signalling in cells without interfering with other growth factor systems and serum proteins unrelated to FGFs.
Related projects:	CEITEC 2020 Polymorfní G-quadruplexy v promotorových oblastech genů