Dynamic functional connectivity in prodromal dementia with Lewy body

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This publication doesn't include Institute of Computer Science. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	GAJDOŠ Martin NOVÁKOVÁ Marie LAMOŠ Martin ŘÍHA Pavel REKTOROVÁ Irena MIKL Michal
Year of publication	2022
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	In this work, we analyzed dynamic functional connectivity in 56 subjects (25 healthy controls and 31 MCI-LB) in order to detect changes related to early signs of neurodegeneration in the fMRI in brain states related to preparation to the action. We used method called sliding window analysis. We found significant differences in dwell time in one of 4 identified brain states. This dwell time significantly correlated with visuospatial memory in MCI-LB group whereas in HC group was no significant correlation present. Observed changes probably reflect compensatory mechanisms of MCI-LB.
Related projects:	Biomarkers of neurodegenerative diseases based on dynamic functional connectivity