Parametry lipidového spektra u pacientek s GDM a zdravých těhotných
| Title in English | Lipid spectrum parameters in GDM patients and healthy pregnant women |
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| Authors | |
| Year of publication | 2024 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Introduction In type 2 diabetes, proatherogenic dyslipidemia has been repeatedly demonstrated as part of the metabolic syndrome. Several studies (as well as our pilot results) suggest that women with GDM have a higher prevalence of metabolic syndrome compared to healthy pregnant women. The objectives of this study were (i) to study differences in lipid levels between pregnant controls and GDM, (ii) to investigate the correlation of lipid levels in pregnancy with the risk of GDM conversion to prediabetes/ postpartum diabetes (PGI), and (iii) to determine whether lipid levels correlate with selected adverse peripartum events. Setting and Methods The study included 109 healthy pregnant and 163 GDM patients, with delivery data available for 77%. Repeat oGTT after delivery was performed in 42% (n=68) of GDM patients and 13% (n=9) had confirmed conversion to PGI. Follow-up data: age at the time of dg. GDM, pre-gestational BMI, lipid profile at the time of dg. GDM (2nd trimester), pre- and post-natal glycaemia, glycaemia during oGTT test and HbA1c in 2nd trimester. and postpartum, and dates of delivery. Results Patients with GDM had significantly lower total cholesterol (TC), LDL and HDL values just before delivery compared to controls, and lipid spectrum values did not differ in the 2nd trimester. Lipid values in the GDM group of PGI patients did not differ from the rest of the GDM patients. |
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