Clinical efficacy and safety of first-line nilotinib or imatinib therapy in patients with chronic myeloid leukemia-Nationwide real life data

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Authors

BELOHLAVKOVA Petra ŽÁČKOVÁ Daniela KLAMOVA Hana FABER Edgar KARAS Michal STEJSKAL Lukas CMUNT Eduard CERNA Olga JEŽÍŠKOVÁ Ivana MACHOVA POLAKOVA Katerina ZAK Pavel JURKOVÁ Tereza CHRÁPAVÁ Marika MAYER Jiří

Year of publication 2024
Type Article in Periodical
Magazine / Source Cancer Medicine
MU Faculty or unit

Faculty of Medicine

Citation
web https://onlinelibrary.wiley.com/doi/10.1002/cam4.70158
Doi http://dx.doi.org/10.1002/cam4.70158
Keywords chronic myeloid leukemia; first-line treatment; imatinib; nilotinib
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Description Background: To evaluate the outcomes of first- line imatinib versus nilotinib treatment for chronic myeloid leukemia in the chronic phase (CML- CP) in real-world clinical practice. Methods: A propensity score analysis was performed to eliminate imbalances between the treatment groups. In the analysis, 163 patients in the nilotinib group and 163 patients in the matched imatinib group were retrospectively evaluated. Results: Nilotinib- treated patients achieved complete cytogenetic response (CCyR) and major molecular response more rapidly than imatinib-treated patients. However, there was no significant difference in 5- year overall survival (OS) or progression- free survival (PFS) between the two groups (OS: 94.3% vs. 90.5%, p = 0.602; PFS: 92.9% vs. 88.0%, p = 0.614). Nilotinib- treated patients had a higher failure- free survival (FFS) and event- free survival (EFS) than imatinib-treated patients (FFS: 71.7% vs. 54.3%, p = 0.040; EFS: 71.7% vs. 53.5%, p = 0.025). Conclusions: This retrospective analysis from clinical practice did not confirm any benefit of frontline nilotinib treatment for OS and PFS; however, it did demonstrate higher FFS and EFS in the nilotinib cohort.
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