Kód fyziologického farmakokinetického modelu (PBPK) v MatLabu pro simulaci časově závislých koncentrací chemických látek v lidském těle

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Title in English	Physiologically Based Pharmacokinetic (PBPK) model code in MatLab for simulating time-dependent concentrations of a chemical in a human body
Authors	DOMÍNGUEZ-ROMERO Elena MAZURENKO Stanislav SCHERINGER Martin MARTINS DOS SANTOS Vítor A.P. EVELO Chris T. ANTON Mihail HANCOCK John M ŽUPANIČ Anže SUAREZ-DIEZ Maria
Year of publication	2024
Type	Software
MU Faculty or unit	Faculty of Science
web	https://doi.org/10.5281/zenodo.13838845
Description	A three-compartment Physiologically Based Pharmacokinetic (PBPK) model coded in MatLab incorporates blood, liver, and a collective representation of other body tissues, diverging from traditional designs by emphasising blood. The model is built on the conceptual framework proposed by Upton et al. (2016) but utilises updated parameter values for adult humans and introduces partition coefficients, enhancing distribution accuracy. Its simplicity and comprehensiveness promote better understanding and ensure interoperability and reusability, adhering to “the Minimum information requested in the annotation of biochemical models (MIRIAM)” set of rules and contemporary recommendations for PBPK model development.
Related projects:	CZECRIN - Czech National Node to the European Clinical Research Infrastructure Network