A Controlled Single-Centre Pilot Study to Evaluate the Effect of Prophylactic Surgery in Asymptomatic Degenerative Cervical Cord Compression
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | GLOBAL SPINE JOURNAL |
| MU Faculty or unit | |
| Citation | |
| web | https://journals.sagepub.com/doi/10.1177/21925682251323862 |
| Doi | http://dx.doi.org/10.1177/21925682251323862 |
| Keywords | asymptomatic degenerative cervical cord compression; degenerative cervical myelopathy; prophylactic surgery |
| Description | Study Design Single-centre controlled pilot study.Objectives To evaluate the effect of prophylactic surgery and to review the biases of a therapeutic trial in asymptomatic degenerative cervical cord compression (ADCC) patients.Methods Patients with ADCC and at least 1 predictor of progression to symptomatic degenerative cervical cord myelopathy (DCM) were offered either prophylactic surgery or standard structured rehabilitation. Recruited patients were clinically followed to detect the development of symptomatic DCM.Results Forty-one patients treated surgically and 68 patients treated non-surgically completed the minimum 36 months' follow-up; 3 recruited patients were lost from evaluation. The surgical group had a higher Neck Disability Index score and more severe MRI compression. A matched subgroup of 41 non-surgical patients was created to reduce potential bias. During the follow-up period we observed progression to symptomatic DCM in 1 surgical case (2.4%) compared to 9 patients in the non-surgical group (13.2%, P = 0.054) and 7 cases in the matched non-surgical group (17.1%, P = 0.029). We observed non-serious early postoperative complications in 4 patients, which resolved spontaneously or after surgical revision. In 9 patients with progression to DCM, the myelopathy was mild with mJOA scale 15-17. One patient in the non-surgical group and 1 patient in the surgical group who progressed to DCM underwent surgery with a good outcome.Conclusions Prophylactic surgery led to a significant decrease in proportion of ADCC patients with progression to DCM. The results justify the organisation of a large randomized multicentre trial that may demonstrate the benefit of prophylactic surgery in ADCC patients. |
| Related projects: |
|