Do AMPA/kainate antagonists possess potential in the treatment of addiction? Evidence from animal behavioural studies

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Authors	HRICKOVÁ Mária RUDÁ Jana
Year of publication	2025
Type	Article in Periodical
Magazine / Source	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.sciencedirect.com/science/article/pii/S0278584625001095?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.pnpbp.2025.111355
Keywords	Alcohol AMPA/kainate antagonist Amphetamine Cocaine Nicotine Opioids
Description	This review examines the potential of AMPA/kainate glutamatergic receptor antagonists in reducing addictive-like behaviours in experimental rodents. To this end, the text summarizes the behavioural results of preclinical studies on stimulant substances (cocaine, amphetamine, methamphetamine, MDMA), nicotine, opioids (morphine and heroin), and alcohol. These experiments employ various protocols and routes of administration, using different strains of mice and rats.
Related projects:	Specific pharmacological research in pharmacokinetics, behavioural neuropsychopharmacology and personalised pharmacotherapy in oncology