Microwave Application in 1,3-Dipolar Cycloadditions and Their Influence upon Formation of either 1,3-Oxazolidines or Pyrrolidines

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Authors	POTÁČEK Milan
Year of publication	2000
Type	Article in Proceedings
Conference	Proceedings - International Conference on Microwave Chemistry
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Description	A way to preparation of ethyl-N-alkyl-3,4-disubstituted pyrrolidine-2-carboxylates by the reaction of azomethine ylide and dipolarophile under microwave irradiation was searched. The ylide was generated in situ by the reaction of ethyl-N-alkylaminoacetates with paraformaldehyde. Fumaronitrile and dimethylfumarate were used as dipolarophiles. Comparison of reaction in toluene and under solventless conditions as well as influence of a solid support was searched.
Related projects:	Chemical transformations activated by microwaves