Nucleic acid sensing by impedance measurements
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Electrochimica Acta |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Keywords | two-dimensional condensation; adsorption; differential capacitance; electrode double layer; electrode impedance |
| Description | The adsorption of cytosine, 5-bromocytosine and native and denatured DNA was follwed by measurement of the impedance of the electrode double layer. The two-dimensional condensation of both cytosine and 5-bromocytosine at the electrode surface results in the formation of a self-assembled compact layer and manifests itself as a capacitance pit on the C-E curves. The pit of 5-bromocytosine occurs around the potential of electrocapillary maximu, the pit of cytosine around -1.4 V. The electrode impedance is affected by the conformation of nucleic acid. |
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