Segregation of nucleolar components coicides with caspase-3 activation in cisplatin-treated HeLa cells

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Authors	HORKÝ Marcel WURZER Gabriele KOTALA Vladimír ANTON Milan VOJTĚŠEK Bořivoj VÁCHA Jiří WESIERSKA-GADEK Jozefa
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Journal of Cell Science
MU Faculty or unit	Faculty of Medicine
Citation
Field	Morphological specializations and cytology
Description	We studied morphological changes of the nucleoli in HeLa cells traeted with cisplatin and compared them with induction of markers of programmed cell death and TUNEL staining. Remarkable segregation of nucleolar argyrophillic proteins, nucleolar RNA and a simultaneous activation of the cascade od caspases markedly preceded the TUNEL positivity in cisplatin-treated heLa cells.
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