Use of S-Mosher acid as a chiral solvating agent for enantiomeric analysis of some trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines by means of NMR spectroscopy

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Authors	NAVRÁTILOVÁ Hana
Year of publication	2001
Type	Article in Periodical
Magazine / Source	Chirality
MU Faculty or unit	Faculty of Informatics
Citation
Field	Organic chemistry
Keywords	spectral non-equivalence; piperidines; NMR; paroxetine
Description	S-Mosher acid induced chemical-shift non-equivalence in NMR spectra of chiral trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines. The magnitude of Dd in 1H and 19F NMR spectra varied with the substituent at position 3 of the piperidine ring. The magnitudes Dd observed for certain protons and for the fluorine in the 4-fluorophenyl group were sufficiently large to allow determination of enantiomeric composition.
Related projects:	Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles