(3R,4S)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine: Conformation and structure monitoring by vibrational circular dichroism

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Authors	BOUŘ Petr NAVRÁTILOVÁ Hana URBANOVÁ Marie SETNIČKA Vladimír VOLKA Karel
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Journal of Organic Chemistry
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Keywords	absolute configuration; VCD; piperidines; paroxetine; femoxetine;
Description	Absorption and vibrational circular dichroism (VCD) spectra of the title compound, a common intermediate in synthesis of many pharmaceuticals, were measured and analyzed in order to determine its absolute configuration and prevailing conformations.
Related projects:	Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles