Office blood pressure, heart rate and interleukin-6 gene polymorphism in apparently healthy Czech middle-aged population
| Authors | |
|---|---|
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Physiological Research |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | heart rate - BMI - smoking - interleukin-6 - gene polymorphism |
| Description | The aim of the study was to assess the existence of association of promoter polymorphism [A (-597)G] in interleukin-6 gene with office systolic and diastolic blood pressures as well as with heart rate in apparently healthy Czech subjects. Another task was to evaluate possible influence of gender, BMI and smoking on these supposed associations. An age- (40-50 years) and sex-matched (F/M=81/89) sample of healthy Czech subjects (n=170,F/M=81/89) without previous personal history of hypertension, other cardiovascular diseases and/ or diabetes was formed. The A (-597) G IL-6 polymorphism was detected by PCR No differences in genotype distribution and/or allelic frequency was found between groups with "low" systolic blood pressure (below 122mm Hg) and "high systolic blood pressure (above 122 mm Hg). Similarly, no differences in the IL-6 polymorphism were found between"low" (below 88 mm Hg) and "high" (above 88 mm Hg) diastolic blood pressure groups. But, significant differences were observed both in genotype (P= 0.006, Pcorr=0.024) and allele distribution (P=0.007, Pcorr=0.021) of the polymorphism between two groups with different heart rate ("low" heart rate group, below 78 beats/min and "high" heart rate group, above 78 beats/min). BMI, smoking status and gender further modified the distributions. While for BMI the genotype/allelic distribution differences were manifested in lean men, the greatest differences associated with smoking status were found in non-smoking women. In both cases, an increase of the allele G (-597) of IL-6 gene polymorphism was found in the higher heart rate groups. |
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