Prvé antipsychotikum 2. generace v depotní formě: Risperidon mikrosféry v intramuskulárních injekcích
| Title in English | The First Antipsychotic of the 2nd generation in a depot form:Risperidone microspheres in intramuscular injections. |
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| Authors | |
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | risperidone depot injections; maintenance therapy of schizophrenia; efficacy and tolerability of risperidone microspheres |
| Description | Risperidone is the first antipsychotic of the 2nd generation that is dstributed in depot injections. Risperidone in the depot form was tested in five 3-4month trials, 3 of which were open and 2 double-blind, and in a single long-term, 50-weeks study, in which the total of 1892 patients treated for schizophrenic and schizoaffective disorders were involved. Risperidone depot injections were more effective than placebo and equally effective as the oral form of the same drug. The most frequent side-effects included extrapyramidal reactions observed in 20-30% of patients depending on the application dose, hyperprolactinemia, mild weight gain, and in 10-15% of patients also headache, somnolence and dyspepsia. Risperidone in the depot form is a preferential choice for maintenance therapy of patients with schizophrenic and schizoaffective disorders who refuse oral administration of drugs or repeatedly discontinue therapy |
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