Role of sigma signalling in mammalian myocardium
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Chronobiological analysis in pathophysiology of cardiovascular system |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | sigma receptor; haloperidol; guinea pig heart; mechanical restitution |
| Description | Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in left atria and papillary muscles isolated from the right ventricles. Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed. The normalized course of mechanical restitution curve was not changed during perfusion with haloperidol. It is concluded that its positive inotropic effect is very likely mediated via increased cytosolic availability of calcium. |
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